Jeanne M . Nerbonne , Colin G . Nichols , Thomas L . Schwarz and Denis Escande and Where Do We Go From Here ? Channel Function in Mice : What Have We Learned

Genetic Manipulation of Cardiac K Channel Function in Mice

In the mammalian myocardium, potassium (K ) channels control resting potentials, action potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple types of K channels that subserve these functions are expressed. Molecular cloning has revealed the presence of a large number of K channel pore forming ( ) and accessory ( ) subunits in the heart, and considerable...

Genetic manipulation of cardiac K(+) channel function in mice: what have we learned, and where do we go from here?

In the mammalian myocardium, potassium (K(+)) channels control resting potentials, action potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple types of K(+) channels that subserve these functions are expressed. Molecular cloning has revealed the presence of a large number of K(+) channel pore forming (alpha) and accessory (beta) subunits in the heart, a...

Functional Consequences of Cantu Syndrome Associated Mutations in the ATP Sensitive Potassium Channel

O24: Functional Role of the K2P Potassium Channel TASK-3 in Glioma

TASK-3, a two-pore-domain (K2P) potassium channel, has been implicated as important regulator for the effector function and proliferation of T-cells. Interestingly, TASK-3 has also a functional impact on tumor cells. Therefore, we sought to investigate whether TASK3 modulation might have a therapeutic potential for malignant gliomas by a variety of phenotypical and functional in vitro assays mi...

A Survey on Complexity of Integrity Parameter

Many graph theoretical parameters have been used to describe the vulnerability of communication networks, including toughness, binding number, rate of disruption, neighbor-connectivity, integrity, mean integrity, edgeconnectivity vector, l-connectivity and tenacity. In this paper we discuss Integrity and its properties in vulnerability calculation. The integrity of a graph G, I(G), is defined t...